MARC details
| 000 -LEADER |
|---|
| fixed length control field |
03013nab a22002657a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
210330s2020 ua gr|pss|||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EAL |
| Transcribing agency |
EAL |
| 041 ## - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| Language code of summary or abstract |
ara |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
|---|
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
ART EJZ V73 JUN 2 |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Atwa, Marwa Th. |
| 240 10 - UNIFORM TITLE |
|---|
| Uniform title |
Egyptian journal of zoology |
| Medium |
[electronic resource] |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Effect of cryptosporidium parvum infection on DNA damage and cytokines gene expression in blood of immunocompromised mice |
| Medium |
[electronic resource]: |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
تأثير العدوي بالطفيلي " Cryptosporidium parvum " علي السمية الوراثية والتعبير الجيني للسيتوكينات فى دم الفئران المثبطة مناعيا |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
p. 16-25. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
|---|
| Bibliography, etc. note |
Includes bibliographic reference |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
There are few data regarding the genotoxic and immuno-modulatory effects of Cryptosporidium parvum (Family: Cryptosporidiidae) infection in vivo. <br/>Therefore, the present study evaluated the effect of Cryptosporidium parvum infection on DNA and gene expressions of interleukin-6 (Il-6) <br/>and tumor necrosis factor-? (Tnf-?) in blood of the immunocompromised mice. Fifty adult male Swiss albino mice were used in the present study; <br/>these were randomly divided into five groups (10 mice/each group) as follows: group I served as a healthy, uninfected control group; groups II-IV <br/>were immunosuppressed by dexamethasone, and uninfected, or infected (orally) with 3.0?103 (low dose) or 1.0?104 (high dose) Cryptosporidium parvum oocysts, <br/>respectively; group V did not receive dexamethasone and infected with 1.0x104 Cryptosporidium parvum oocysts. DNA damage of leucocytes was assessed <br/>by flow cytometry and comet assay; the gene expression of the cytokines was performed using real-time polymerase chain reaction. The results revealed <br/>that infection with the low or the high dose of Cryptosporidium parvum induced DNA damage in the leucocytes of the immunosuppressed mice, as revealed <br/>by the elevations in tail length and tail moment of the comet assay compared with the healthy and immunosuppressed, uninfected, mice. In addition, <br/>significant decreases and increases in the expression of Il-6 and Tnf-? genes, respectively, were recorded in leucocytes of the immunosuppressed, <br/>Cryptosporidium parvum-infected mice in comparison with the healthy and immuno-suppressed, uninfected, mice. In conclusion, Cryptosporidium infection <br/>induced DNA damage and augmented the changes induced in the Il-6 and Tnf-? gene expressions in the leucocytes of the immunosuppressed mice.<br/>Cryptosporidium parvum<br/>DNA damage<br/>IL-6<br/>Swiss albino mice<br/>TNF-?<br/><br/> |
| 546 ## - LANGUAGE NOTE |
|---|
| Language note |
Summary in Arabic |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Cryptosporidium parvum |
| 9 (RLIN) |
28897 |
| 650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
DNA Damage |
| General subdivision |
physiology |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Salem, Noha I. S. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mohamed, Hanan R. H. |
| 773 #0 - HOST ITEM ENTRY |
|---|
| Title |
Egyptian Journal of Zoology |
| Related parts |
2020.v.73 |
| International Standard Serial Number |
2682-3160 |
| Record control number |
66557 |
| Control subfield |
nnas |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Uniform Resource Identifier |
http://nile.enal.sci.eg/EALE/2020/EJZ/7320/JUN/16.pdf |
| Public note |
Full Text Article |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
alc |
| Articles |
AR |