Clinicopathological studies on the role of urinary enzymes in the diagnosis of nephrotoxicity in dogs [electronic resource].

Includes references.

It Was reported that lack of early biomarkers for diagnosis of acute renal failure is consldered the most important problem hinder the effective therapeutic strategies. This study was performed on fourteen apparently healthy adult male dogs with a mean weight of 13.5 kg, They were demonstrated normal renal function before the study. Dogs were equally divided into two groups each of which contained 7 dogs. Group 1 was kept as a nonnal control .Group 2 was intramuscularly injected with gentamicin 10mglkg B,W/d for 17 days. Blood samples were taken from cephalic vein from seven dogs in each group at 6,S, 10,12,13,14,15,16 and 17 days post treatment. Also random urine samples were collected by cystocentesis and used for estimation of urinary enzymes, Specimens were taken from kidney at 15 and 17 days post treatmcnt for histopathological examination.

Summary in Arabic.

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