TY - SER AU - Donya,Souria M. AU - Aly,Fawzia A. AU - Abo-Zeid,Mona A.M. TI - The protective role of folic acid, vitamin B12 and vitamin C on the mutagenicity of the anticancer drug ifosfamide KW - Folic acid KW - Physiological effect KW - Vitamin B12 KW - Vitamin C KW - DNA damage KW - Antineoplastic agents KW - Cancer KW - Treatment N1 - Includes references N2 - Ifosfamide (Holoxan, IFO) is an oxazaphospoorine alkylating agent with a broad spectrum of antineoplastic activity. IFO can damage DNA during any phase of the celI cycle and therefore, is not phase-specific. Thus the objective of this investigation is to measure the potential cytotoxicity of IFO alone and in combination with vitamins (FA, VB12 and VC) The genotoxic potential of IFO was evaluated in vivo using different mutagenic end points UR - http://nile.enal.sci.eg/EALE/2009/JGEB/709/2/41.pdf ER -