Clinicopathological and toxocological studies on the effect of vanadium pentoxide as anticarcinogenic [electronic resource].
دراسات باثولوجية إكلينيكية على تأثير خامس أكسيد الفاناديوم كمضاد للسرطان.
- p.75-87.
Includes references.
Vanadium (V) is a heavy metal and trace element. It is believed to be a novel anticarcinogenic agent. It helps in the protection against the cancer induced by dimethylbenzantheracene (DMBA), adenocarcinoma in female-albino rats. One hundred and five female rats were divided into four gps. Gp.(I), 15 rats, was the negative control. Gp.(2), 30 rats, was orally intubated by vanadium pentoxide (0.05mglkg B.wt for 150 days), Gp.(3), 30 rats, was orally given DMBA(lOOmglkg B.wt, the dose was divided into 4 weekly applications, dissolved in corn oil.. Gp.(4) , 30 rats, was orally given vanadium (0.05mglkg B.wt for 150 days). Four weekly oral doses of DMBA, dissolved in corn oil were given after one month from the start of vanadium which continued for 150 days. Blood samples were collected from the retroorbital venous plexus for hematological and biochemical studies after 90, 120 and 150 days from the beginning of the experiment. Specimens were taken at the same time from the liver, kidneys, lungs, spleen, mammary glands, oviduct and ovaries for histopathological examination after sacrifice of the rats.