TY  - SER
AU  - Meshreky,Samia Z.
AU  - Ahmed,Fatma G.
AU  - Arafa,Mervat M.
AU  - Abo warda,M.A.
TI  - Effectiveness of detoxifying agents of rabbit bucks feed contaminated with aflatoxin
KW  - Rabbits
KW  - Feeding and feeds
KW  - Nutrition
KW  - Physiology
KW  - Reproduction
KW  - Aflatoxins
KW  - Physiological effect
KW  - Toxicology
N1  - Includes references
N2  - Some detoxifying agents were evaluated for its ability to reduce the deleterious effects of aflatoxins in rabbit bucks diets. Thirty six Bouscat rabbit bucks at 10-12 months of age with an average body weight of 3.46±0.12 kg were divided into six homogeneous groups (n=6). The 1st group was fed a basal diet including 0.1% commercial anti-fungal agent (sodium propionate) as a control. The other groups were fed the same basal diet of which 40% were replaced with diet naturally contaminated with 450 ppb aflatoxins. The 2nd group was kept without supplementation as an aflatoxin diet (AF-diet). The 3rd to 6th groups supplemented with 2 or 4 g bentonit or tafla clay/kg diet, respectively. Aflatoins contamination clearly changes the chemical analysis of the rabbit bucks diets, decreased dray matter, crude protein and nitrogen free extract, increased ether extract and crude fiber compared to control one. Body weight and feed intake linearly decreased (P<0.001) in bucks group fed aflatoxins diet with commercial antifungal agent alone (2nd group) with the progress of feeding duration, which had the lowest body weight and feed consume than the other groups. Feed aflatoxicated diet with commercial anti-fungal agent alone (2nd group) and increasing feeding duration suppressing (P<0.001) libido, decreased (P<0.001 or 0.01) sperm cell concentration (x106/ ml) and sperm motility score, testosterone concentration, fertilizing ability and litter size at birth, while dead sperm and sperm abnormalities percentages tended to increase than those fed control diet. Testes, liver and kidneys weights and structures adversely affected by aflatoxins consumed with different detoxifying agents, except 0.4% bentonite. Bucks fed AF-diet with commercial anti-fungal agent alone showed atrophy in semineferous tubules of the testes and low numbers of spermatozoa and degenerated spermatozoa were detected in the semineferous tubules and epididymis compared with the other groups fed AF-diets supplemented with clay. Histopathological findings showed the amelioration of AF-diet toxic effects was not as high as predicted in all detoxifying agents supplementation for liver and kidneys. A decrease (P<0.001 or 0.01) in plasma total protein, albumin and globulin levels and an increase (P<0.001 or 0.01) in AST, ALT and AP (liver function) and urea and creatinine (kidney function) concentrations were observed in bucks fed AF-diet with commercial anti-fungal agent alone, especially with advancement of feeding. Inclusion 0.4% bentonite to AF-diets alleviated markedly the harmful effects of aflatoxicosis on all criteria studied especially with increasing feeding duration, followed by 0.4% tafla and 0.2% bentonite, respectively. The present investigation clearly indicates that commercial anti-fungal agent used in this study showed almost negligible results against aflatoxicoses and the clays differed in their ability to diminish the negative effects of aflatoxicosis. Inclusion 0.4% bentonite to aflatoxin contaminated diet ameliorates aflatoxin-induced changes in reproductive characteristics of rabbit bucks
UR  - http://nile.enal.sci.eg/EALE/2010/EJRS/conf/10/feb/391.pdf
ER  -