TY  - SER
AU  - Salama,Ali A.
AU  - Ali,Ahmed Abdel Samie H.
AU  - Zeidan,Sayed M.
AU  - Mansour,Shimaa M.G.
TI  - Experimental studies on the effect of neomycin B on rotavirus replication
KW  - Rotaviruses
KW  - Viruses
KW  - Reproduction
KW  - Neomycin
KW  - Aminoglycosides
KW  - Therapeutic use
KW  - Calves
KW  - Vaccination
N1  - Includes references
N2  - Bovine Rotavirus (BRV) is a major cause of acute gastroenteritis in newborn calves throughout the world causing economic losses to beef and dairy industries. Neomycin B, an aminoglycoside antibiotic has been shown to inhibit rotavirus replication in-vitro. The current study was carried out to study the availability of neomycin B as preventive and chemotherapeutic mean for rotavirus infection, It was conducted by following up the replication of virus inside the infected and infected treated mice. Moreover the shedding of virus by infected and infected treated mice was determined by immunofluorescence (IF). The group of mice inoculated with BRV and simultaneously treated with neomycin had significant reductions in virus shedding by 1.43 and 1.7 logs at first day and 5th day post BRV inoculation respectively. It was revealed that neomycin has an interfering effect on rotavirus replication in-vivo (in mice), when the drug administered before, during and after viral infection. Further studies for field applications of neomycin as therapeutic measure for Bovine Rotavirus infection in newborn calves especially in calves born from non vaccinated animals or born with low titer of antibodies need to be done
UR  - http://nile.enal.sci.eg/EALE/2009/ZVJ/3709/4/137.pdf
ER  -