TY  - SER
AU  - Ibrahim,A.L.
AU  - El-Ghannam,A.A.
AU  - Shalaby,Abeer A.
AU  - Bahr,Hoda I.
TI  - The antioxidant effect of different doses of chromium chloride supplementation in rats
KW  - Rats
KW  - Diseases
KW  - Chromium chloride
KW  - Antioxidants
N1  - Includes references
N2  - The present work was done to elucidate the possible protective and antioxidant effect of low and high doses of chromium chloride supplementation in rats. The experiment was carried out on 63 adult male Sprague Dawley rats weighing 150-200 g. Rats were randomly divided into three equal groups each had 21 rats as follow; group I (control), group II (low dose) of chromium chloride (0.8 µg/ml drinking water) and group III (high dose) of chromium chloride (4 µg Iml drinking water). Blood samples were collected after 2, 4 & 6 weeks for assessment of erythrocytes antioxidants. Glutathione (GSH) content and the activity of superoxide dismutase (SOD) and catalase (CAT) as well as glutathione S-transferase (GST) were elevated by both doses of Cr than control during the whole period of experiment. Moreover, an increase in glutathione peroxidase (GSH-px) activity was observed after 4 & 6 weeks in chromium low dose (CLD)-treated group and during whole period of the experiment in chromium high dose (CHD)-treated group. It could be concluded that, administration of chromium at high dose (CHD) reveals the potent antioxidant. Key words: Chromium chloride, dose, antioxidant effect, rats
UR  - http://nile.enal.sci.eg/EALE/2011/SCVMJ/1611/1/115.pdf
ER  -