Red ginseng extract and selenium reduce oxidative stress induced by potassium bromate in male rats [electronic resource].
خلاصة نبات الجنسنج الأحمر والسلينيوم تقلل من الإجهاد التأكسدى فى ذكور الفئران المحدث ببرومات البوتاسيوم.
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Includes references.
The effect of red ginseng extract (RGE) and selenium (Se) on potassium bromate (KBr03)-induced oxidative stress in rats was investigated. Fifty mature male rats were used in this study and randomly distributed into 5 groups (n=1O). Group (1) was kept as a negative control and the other 4 groups were injected with a single intraperitoneal dose ofKBr03 (125 mg/kg/BW) to induce oxidative stress. Group (2) was kept as a positive control and groups (3), (4) and (5) were orally given RGE (200 mg/kg/ BW), Se (0.5 mg/kg/ BW) and RGE and Se, daily for 8 weeks, respectively. At the end of experiment, blood samples were collected and livers were taken for biochemical analyses. The results showed that oxidative stress induced by KBr03 in rats caused significant decreases in body weight gain and feed efficiency ratio. It also passively affected biomarkers of hepatorenal function, increased lipid peroxidation and decreased the activity of antioxidant enzymes (GPX, SOD and CAT) in liver tissues. Oral administration of RGE increased weight gain and feed efficiency ratio. RGE also improved hepatorenal function, decreased lipid peroxidation and normalized biomarkers of oxidative stress. These effects were amplified by coadministration of red ginseng extract with selenium and this might be attributed to the addition effect. In conclusion, coadministration of red ginseng plant and selenium induces high antioxidant activity as it markedly reduces oxidative stress biomarkers in rats. Therefore intake of red ginseng and selenium may be beneficial for patients with oxidative stress which is linked as a main cause of many diseases. Key words: Red Ginseng; Selenium; Oxidative stress; Potassium bromate Antioxidants; Hepatorenal function; Biochemistry; Rats.