TY  - SER
AU  - Shalaby,Omnia E.
AU  - Ahmed,Yasmine H.
AU  - Mekkawy,Aya M.
AU  - Elbargeesy,G.A.
TI  - Ultrastructural study on the hepatoprotective effect of selenium-loaded chitosan nanoparticles against silver nanoparticles-induced toxicity in the female albino rats
PY  - 2023///
KW  - Metal nanoparticles
KW  - Selenium compounds
KW  - Hepatotoxicology	
N1  - Includes references
N2  - Silver nanoparticles (Ag-NPs) are increasingly used in industrial and biological 
applications. There are growing worries regarding their toxicity to both humans and 
animals. Selenium-loaded chitosan nanoparticles (CS-SeNPs) have strong antioxidant 
properties via scavenging free radicals. The aim of this study is to assess the protective 
effect of CS-SeNPs against Ag-NPs' damaging effects on the hepatic tissue of adult female 
rats. Forty female albino rats were separated into four groups: group I (control) was given 
distilled water (0.5 ml/kg), group II was administered Ag-NPs (100 mg/kg), group III was 
co-exposed with Ag-NPs (100 mg/kg) and CS-SeNPs (0.5 mg/kg) and group IV received 
only CS-SeNPs (0.5 mg/kg) daily by oral gavage. After 60 days, rats were euthanized, then 
hepatic tissues were collected and fixed in 5% glutaraldehyde for transmission electron 
microscopy. Exposure to Ag-NPs induced severe degeneration of the hepatocytes, in the 
form of complete lysis and disappearance of the cytoplasmic organelles. While 
supplementation with CS-SeNPs exhibited a partial disappearance of most degenerative 
changes induced by Ag-NPs. In conclusion, Ag-NPs induce some destructive effects on 
the hepatic tissue and CS-SeNPs can ameliorate most of these harmful effects.

Keywords: Silver nanoparticles; Selenium-loaded chitosan nanoparticles; Hepatotoxicity; Ultrastructure

UR  - http://nile.enal.sci.eg/cgi-bin/koha/opac-retrieve-file.pl?id=33b2476b5f5fb515bdab921074e6b0c0
ER  -