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Glucose starvation induced autophagt is A potent apopotic cell death mechanism in multidrug resistant HL60/ADR cells [electronic resource].

By:

Abdel-Shakor, A-B. M

Language: English Summary language: Arabic Description: P. 1-16Other title:

الالتهام الذاتي الناتج عن صوم الجلوكوز يؤدي إلى موت خلوي مبرمج فعال في خلايا [Added title page title]

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Assiut veterinary medical journal, 2010 v. 56 (124) [electronic resource].

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In: Assiut Veterinary Medical Journal 2010.v.56(124)Summary: Multidrug resistance in cancer is significantly limits the effectiveness of cancer chemotherapy. The main pupose of the present study is to investigate the role of autophagy induced by glucose starvation in apoptosis induction in multidrug resistant human leukaemia HL60/ADR cell line. The present data indicates that glucose starvation induced autophagy as determined by the level of LC3 protein (autophagy marker), whereas serum deprivation did not induce autophagy at the same time points.

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Multidrug resistance in cancer is significantly limits the effectiveness of cancer chemotherapy. The main pupose of the present study is to investigate the role of autophagy induced by glucose starvation in apoptosis induction in multidrug resistant human leukaemia HL60/ADR cell line. The present data indicates that glucose starvation induced autophagy as determined by the level of LC3 protein (autophagy marker), whereas serum deprivation did not induce autophagy at the same time points.

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