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Effect of diminazine aceturate on the pharmacokinetic of a long acting oxytetracycline formulation in lactating goats [electronic resource].

By:

Youssef, S. Abd El-Hamid

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Language: English Summary language: Arabic Description: P. 31-48Other title:

تأثير الداى مينازين اسيتيورات على المسار الحركى لتركيبة الأوكسى تتراسيكيلين طويل المفعول فى الماعز الحلوب [Added title page title]

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Veterinary medical journal, 2010 v.58 (1) [electronic resource].

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In: Veterinary Medical Journal 2010.v.58(1)Summary: Oxytetracycline (OTC) and diminazene aceturate are commonly administered to diseased ruminants with mixed bacterial and protozoal infections. We were therefore interested in characterizing the pharmacokinetics of a new long acting OTC formulation after IV or 1M administration, and whether concurrent administration of diminazene altered the pharmacokinetics. Ten clinically healthy lactating female Baladi goats were used in a sequential order. Goats received the treatments in sequential order with a 2 week wash out period between each study: 1) a single dose of OTC (30 mg/kg BW) by IV or 1M injection in non-treated and diminazine aceturate pre-treated goats (3.5 mg/kg BW) 2 hours before OTC treatment. Blood, milk and urine samples were collected periodically and OTC concentration was assayed using a microbiological method.

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Oxytetracycline (OTC) and diminazene aceturate are commonly administered to diseased ruminants with mixed bacterial and protozoal infections. We were therefore interested in characterizing the pharmacokinetics of a new long acting OTC formulation after IV or 1M administration, and whether concurrent administration of diminazene altered the pharmacokinetics. Ten clinically healthy lactating female Baladi goats were used in a sequential order. Goats received the treatments in sequential order with a 2 week wash out period between each study: 1) a single dose of OTC (30 mg/kg BW) by IV or 1M injection in non-treated and diminazine aceturate pre-treated goats (3.5 mg/kg BW) 2 hours before OTC treatment. Blood, milk and urine samples were collected periodically and OTC concentration was assayed using a microbiological method.

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