000			01709cab a2200301Ia 45 0
999			_c64061 _d64061
001			u158990
003			ENAL
008			100228s2015 ua ss b 0 eng d
040			_aEAL _cEAL
041			_aeng _bara
090			_aART AAS V60 No2 17
100	1		_aKhalil, Ayman F. _924585
240	1	0	_aAnnals of agricultural science, 2015 v. 60 (2) _h[electronic resource].
245	1	0	_aProtective effect of peppermint and parsley leaves oils against hepatotoxicity on experimental rats _h[electronic resource].
300			_aP. 353-359
504			_aIncludes reference.
520			_aIn the present study, the protective effect of peppermint (Mentha piperita) and parsley (Petroselinum crispum) leaves oils against hepatotoxicity is induced by carbon tetrachloride (CC14) in experimental rats. GCjMS results indicated that the main components in peppermint oil were menthol (35.9%) and menthone (25.6%), while in parsley oil were ex-Pinene (26.6%) and Myristicin (20.3%). Hepatotoxicity by CC14 resulted in significant elevation of serum triglycerides, total cholesterol, low density lipoprotein (LDL-C), very low density lipoprotein (VLDL-C) and decreasing in serum high density lipoprotein (HDL-C). Moreover, kidney function tests for serum urea nitrogen, creatinine, and uric acid were found to be increased. Administration of 0.5 ml of each peppermint, parsley and their mixture oils attenuated the adverse effects and biochemical alterations caused by CC14 especially, at 0.5 ml of peppermint oil. CC14 caused significant increase in liver lipid peroxidation malondialdehyde (MDA) and significant decrease in liver antioxidant enzymes activity as superoxide dismutase (SOD) and glutathione (GSH). Peppermint, parsley and their mixture oils have strong radical scavenging activity and antioxidant activity specially, at 0.5 ml of peppermint oil that reversed these negative changes by significant increase in the activity of SOD, GSH and decreasing in MDA. Therefore, the results of this study show that peppermint, parsley and their mixture oils led to the protective effect against CC14 hepatotoxicity specially, peppermint oil. The results also revealed that the hepatoprotective effect of peppermint and parsley oil may be attributed to its antioxidant content and free radical scavenger effects
546			_aSummary in Arabic
650		0	_aPeppermint oil _919012
650		0	_aParsley _924586
650		0	_aHepatotoxicology _915340
700	1		_aElkatry, Haiam 0. _924587
700	1		_aEl Mehairy, Hanaa F. _924588
773	0		_tAnnals of agricultural science. _g2015.v.60(2) _x0570-1783 _7nnas _wu157971
856	4	0	_uhttp://nile.enal.sci.eg/EALE/2015/AAS/6015/2/353.pdf _zFull Text Article.
942			_cAR _2alc