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| 001 | u193882 | ||
| 003 | ENAL | ||
| 008 | 170407s2017 ua ss b eng d | ||
| 040 |
_aEAL _cEAL |
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| 041 |
_aeng _bara |
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| 090 | _aART ASEJ V38 No1 10 | ||
| 100 | 1 |
_aHamed, Nadia A. _924956 |
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| 240 | 1 | 0 |
_aAlexandria science exchange journal, 2017 v. 38 (1) _h[electronic resource]: |
| 245 | 1 | 0 |
_aProtective effect of quercetin against oxidative Stress and mitochondrial bioenergetic deficiency caused by lambda- cyhalothrin _h[electronic resource] |
| 246 | 1 | 5 | _aالتأثير الوقائى للكيرسيتين ضد الاكسدة و نقص الطاقة البيولوجية فى الميتوكوندريا التى يسببها لامبادا سيهالوثرين |
| 300 | _aP. 83-88 | ||
| 504 | _aIncludes references. | ||
| 520 | _aMitochondria are a convenient model to understand the oxidative damage induced by various xenobioticprooxidants. This study was designed to investigate (1) the possibility of lambda-cyhalothrin (LCT), a type II pyrethroid, to induce oxidative stress response in rabbit liver mitochondria in vitro and its effect on selected parameters and (2) the role of quercetin in alleviating the cytotoxic effects of LCT. Mitochondria were divided into two groups. The first group, mitochondria were incubated for 30 min at 37oC with different concentrations (0, 5, 10, 15 and 20uM) of LCT. In the second group, mitochondria were pre-incubated with (10µM) quercetin for 30 min and followed by LCT incubation for 30 min at 37oC. Following in vitro exposure, LCT caused a significant induction of oxidative damage in mitochondria at all tested concentrations as evidenced by increased superoxide dismutase (SOD) activity and reduced glutathione (GSH) level. However, a significant decrease in the activities of NADH dehydrogenase and ATP synthase (ATPase) was obtained. While the quercetin treated mitochondria showed significant enhancement in all tested parameters except GSH content, there was no significant change. Quercetin showed a significant protection against the cytotoxic effects induced by LCT on the studied parameters. In conclusion, antioxidant quercetin could be able to ameliorate LCT-induced oxidative stress by altering antioxidant defense system and recovered the bioenergetic activity of mitochondria. | ||
| 546 | _aSummary in Arabic. | ||
| 650 | 0 |
_aQuercetin _924957 |
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| 650 | 0 |
_aOxidative stress _91489 |
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| 650 | 3 |
_alambda-cyhalothrin _924958 |
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| 650 | 0 |
_aBioenergetics _913993 |
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| 700 | _924941 | ||
| 773 | 0 |
_tAlexandria Science Exchange Journal. _g2017.v.38(1) _x1110-0176 _7nnas _wu193445 |
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| 856 | 4 | 0 |
_uhttp://nile.enal.sci.eg/EALE/2017/ASEJ/3817/1/82.pdf _zFull Text Article |
| 942 |
_cAR _2alc |
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