Assessment of the possible protective role of olive oil on iron sulfate induced genotoxicity using chromosomal aberration assay and rapd-PCR in male mice (Record no. 64030)
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| 000 -LEADER | |
|---|---|
| fixed length control field | nab a22 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | ENAL |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 050319s2018 ua n ss b a eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EAL |
| Transcribing agency | EAL |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | ara |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | ART AJVS V59 No1 19 |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Hassaneen, Nahla H. |
| 9 (RLIN) | 1525 |
| 240 10 - UNIFORM TITLE | |
| Uniform title | Alexandria journal of veterinary science, 2018 v. 59 (1) |
| Medium | [electronic reource]. |
| 245 10 - TITLE STATEMENT | |
| Title | Assessment of the possible protective role of olive oil on iron sulfate induced genotoxicity using chromosomal aberration assay and rapd-PCR in male mice |
| Medium | [electronic reource]. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | p. 157-169. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Includes references. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | This study was conducted to evaluate the genotoxic effects of iron sulfate on mice through the assessment of chromosomal aberration, <br/>mitotic activity and DNA fragmentation by RAPD-PCR, as well as screening for the possible ameliorating effect of extra-virgin olive oil <br/>(EVOO) against iron sulfate genotoxicity. Sixty-four swiss albino male mice (Mus musculus), weighing from 25 to 35 gm were used in the study. <br/>Forty mice were used in the acute study for 24 and 48 hrs and twenty-four were used for chronic treatment (six weeks). In both acute studies, <br/>the mice were divided into five groups, the first group acts as a control without any treatment. The second group received 75 ?l EVOO on a diet <br/>for one day before samples collection. The third group received 61.2 mg/kg b.wt iron in a diet which represents 1/5 of its oral LD50, the fourth <br/>group received the same previous doses of EVOO and iron sulfate at the same time. The fifth group received EVOO as a pre-treatment for one week <br/>then received iron sulfate with the previous dose for 24 hrs. Four similar experimental groups were also used for chronic study with 15.3 mg/kg b.wt <br/>iron sulfate in the diet which represents 1/20 of its oral LD50 and the same dose of EVOO as a co-treatment. Iron sulfate in mice ration was able <br/>to produce structural chromosomal aberration in acute treatment and structural and numerical in chronic treatment, lowering mitotic activity and <br/>induced DNA fragmentation (RAPD fragments) at both treatments. EVOO as a co-treatment or pre-treatment leads to decrease in chromosomal aberration <br/>especially chromatid breaks, chromatid deletion and fragments in acute treatment. In general, EVOO as a co-treatment showed a significant role in <br/>lowering Iron sulfate genotoxicity in acute treatments.<br/> |
| 546 ## - LANGUAGE NOTE | |
| Language note | Summary in Arabic |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Chromosome abnormalities. |
| 9 (RLIN) | 24435 |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Ferrous sulfate |
| 9 (RLIN) | 24436 |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hemeda, Shabaan A. |
| 9 (RLIN) | 19299 |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | El-Nahas, Abeer F. |
| 9 (RLIN) | 24437 |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Abd El Naby, Walaa S.H. |
| 9 (RLIN) | 24438 |
| 773 0# - HOST ITEM ENTRY | |
| Title | Alexandria Journal of Veterinary Science. |
| Related parts | 2018.v.59(1) |
| International Standard Serial Number | 1110-2047 |
| Control subfield | nnas |
| Record control number | u191343 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | http://nile.enal.sci.eg/EALE/2018/AJVS/5918/1/157.pdf |
| Public note | Full Text Article. |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Articles | AR |
| Source of classification or shelving scheme | alc |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Date acquired | Total Checkouts | Full call number | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Alphabetical Classification | Main | Main | 03/05/2019 | ART AJVS V59 NO1 19 | 03/05/2019 | 03/05/2019 | Articles |