Nephrotoxicity of 5-fluorouracil in male mice and the probable protective role of vitamin c | [electronic resource]: (Record no. 66629)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02962nab a22002657a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 210316s2019 ua gr|pss|||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EAL |
| Transcribing agency | EAL |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | ara |
| 043 ## - GEOGRAPHIC AREA CODE | |
| Geographic area code | f-ua |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | ART EJZ V72 DEC 4 |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Sabry, Sahar A. |
| 240 10 - UNIFORM TITLE | |
| Uniform title | Egyptian journal of zoology |
| Medium | [electronic resource] |
| 245 10 - TITLE STATEMENT | |
| Title | Nephrotoxicity of 5-fluorouracil in male mice and the probable protective role of vitamin c |
| Medium | [electronic resource]: |
| Remainder of title | Histological and ultrastructural studies |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | السُمية الكُلوية لعقار فلورويوراسيل في ذكور الفئران والدور الوقائي المحتمل لفيتامين ج: دراسات نسيجية وتركيبية دقيقة |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | p. 32-44. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Includes bibliographic reference |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | The present study investigated the probable protective role of vitamin C in alleviating 5-fluorouracil (5-FU)-induced nephro-toxicity <br/>in male mice (Mus musculus). Thirty male CD-1 mice were equally divided into three groups: Group I (the control group), received 0.9% NaCl; <br/>group II, received intraperitoneally (i.p.) 80 mg 5-FU/kg body weight (b.wt)/day for four weeks; group III, received (i.p.) 80 mg 5-FU <br/>plus 12 mg vitamin C/kg b.wt/day for four weeks. Animals of all groups were killed at the end of the experiment, and the renal tissue samples <br/>were taken and processed for light and electron microscopical examinations. Light microscopic observations revealed that administration of <br/>5-FU caused erosion of the parietal cells of Bowman's capsules, widening of the urinary spaces, and disruption of the glomerular <br/>capillaries and hemorrhage. The cells of the proximal and distal tubules exhibited vacuolar degeneration and coagulative necrosis. <br/>The nuclei of these cells manifested pyknosis and karyolysis. Ultrastructural examination revealed damage of the parietal epithelium <br/>of Bowman's capsules with fusion and destruction of the foot processes of the podocytes. The cells of the proximal tubules displayed <br/>destruction of the microvilli constituting the brush borders and degeneration of the mitochondria. The distal tubules displayed destruction <br/>of both the basal infoldings and the mitochondria with fragmentation of the rough endoplasmic reticulum. Histological and ultrastructural results <br/>revealed that the treatment with vitamin C simultaneously with 5-FU led to apparent protection of the renal tissue. This might suggest that vitamin C <br/>has a protective potential against 5-FU-induced nephrotoxicity.<br/>5-Fluorouracil<br/>CD-1 mice<br/>Nephrotoxicity<br/>Ultrastructure<br/>Vitamin C<br/><br/> |
| 546 ## - LANGUAGE NOTE | |
| Language note | Summary in Arabic |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Nephrotoxicology |
| General subdivision | Case studies |
| 9 (RLIN) | 3944 |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Vitamin C |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sakr, Samia M. |
| 773 #0 - HOST ITEM ENTRY | |
| Title | Egyptian Journal of Zoology |
| Related parts | 2019.v.72 |
| International Standard Serial Number | 2682-3160 |
| Record control number | 66557 |
| Control subfield | nnas |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | http://nile.enal.sci.eg/EALE/2019/EJZ/7219/DEC/32.pdf |
| Public note | Full Text Article |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | alc |
| Articles | AR |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Date acquired | Total Checkouts | Full call number | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Alphabetical Classification | Main | Main | 03/16/2021 | ART EJZ V72 DEC 4 | 03/16/2021 | 03/16/2021 | Articles |