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Reproductive toxicity of Bacillus thuringiensis bio-pesticide in male albino rats [electornic resource].

By:

Zidan, N.A

Contributor(s):

Eissa, F.I

Language: English Summary language: Arabic Description: p.217-225Other title:

السمية التناسلية للمبيد الحيوي باسيللس ثيورينجينسيس على ذكور الفئران البيضاء.‪‪‪‪‪ [Added title page title]

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Arab universities journal of agricultural sciences, 2009 v. 17 (1) [electronic resource].

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Full Text Article.

In: Arab Universities Journal of Agricultural Sciences 2009.v.17(1)Summary: The persent study is a trial to investigate the toxic effects of the bio-pesticide Bacillus thuringiensis (Bt) on male reproductive system of rats. Rats received dietary doses each approximately equivalent to 1/10 or 1/100 of the LD₅₀ value of the Bt bio-pesticide (Agerin) for 90 concentrations of the hormones [i.e., testosterone, luteinizing hormone (LH), and follicle stimulating hormone (FSH)], and histopathological changes in testes and seminal vesicles as compared with control. Both Bt doses decreases sperm count associated with an increase in teh morphologically abnormal spermatozoa; however sprem motility was significantly decreased in treated rats with the higher dose only. The concentration of serum testosterone was significantly reduced in both treated groups; however LH and FSH levels were significasntly reduced in treated rats with the higher dose. Histopathological examination of Agerin-treated male rat's testes revealed that both Bt doses caused testicular degeneration in a dosedependent manner. In conclusion, Agerin may decreases fertility in adult male rats by affecting the concentrations of pituitary gonadotrophins, testosterone and thus subsequent spermatogenic impairment.

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The persent study is a trial to investigate the toxic effects of the bio-pesticide Bacillus thuringiensis (Bt) on male reproductive system of rats. Rats received dietary doses each approximately equivalent to 1/10 or 1/100 of the LD₅₀ value of the Bt bio-pesticide (Agerin) for 90 concentrations of the hormones [i.e., testosterone, luteinizing hormone (LH), and follicle stimulating hormone (FSH)], and histopathological changes in testes and seminal vesicles as compared with control. Both Bt doses decreases sperm count associated with an increase in teh morphologically abnormal spermatozoa; however sprem motility was significantly decreased in treated rats with the higher dose only. The concentration of serum testosterone was significantly reduced in both treated groups; however LH and FSH levels were significasntly reduced in treated rats with the higher dose. Histopathological examination of Agerin-treated male rat's testes revealed that both Bt doses caused testicular degeneration in a dosedependent manner. In conclusion, Agerin may decreases fertility in adult male rats by affecting the concentrations of pituitary gonadotrophins, testosterone and thus subsequent spermatogenic impairment.

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