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Syntnesis and fungitoxicity of some natural and synthetic flavones [electronic resource].

By:

Selim, Doaa S

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Language: English Summary language: Arabic Description: p.363-375Other title:

تخليق والسمية ضد الفطريات لبعض الفلافونات المخلقة والطبيعية.‪ [Added title page title]

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Journal of biological chemistry and environmental sciences, 2008 v. 3 (1) Part II [electronic resource].

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In: Journal of Biological Chemistry and Environmental Sciences 2008.v.3(1)IISummary: Two natural flavones (flavone and 4'-methoxyflavone) and two artificial ones (3 '-methylflavone and 4'-bromoflavone) were synthesized using Baker-Venkatarman rearrangement then characterized by spectroscopic techniques. The prepared flavones along with the natural flavones quercetin and chrysin were used to examine the effect of structural variations on the fungitoxicity of flavones. Results indicated correlation between the hydrophobicity and the fungitoxicity of flavones against Alternaria alternatae (R = 0.915) and Fusarium oxisporum (R = 0.562). The conclusion is also applicable on the natural flavones, quercetin and chrysin, with five and two hydroxyl groups respectively since their activities against both organisms increased with increasing their hydrophobicity i.e. chrysin> quercetin.

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Two natural flavones (flavone and 4'-methoxyflavone) and two artificial ones (3 '-methylflavone and 4'-bromoflavone) were synthesized using Baker-Venkatarman rearrangement then characterized by spectroscopic techniques. The prepared flavones along with the natural flavones quercetin and chrysin were used to examine the effect of structural variations on the fungitoxicity of flavones. Results indicated correlation between the hydrophobicity and the fungitoxicity of flavones against Alternaria alternatae (R = 0.915) and Fusarium oxisporum (R = 0.562). The conclusion is also applicable on the natural flavones, quercetin and chrysin, with five and two hydroxyl groups respectively since their activities against both organisms increased with increasing their hydrophobicity i.e. chrysin> quercetin.

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