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Effect of profenofos on haemogram and thyroid gland in male albino rats [electronic resource].

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Farid, M.M

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Language: English Summary language: Arabic Description: p.67-80Other title:

تأثير المعاملة بالبروفينوفوس على الدم والغدة الدرقية في ذكور الفئران البيضاء [Added title page title]

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Journal of biological chemistry and environmental sciences, 2007 v. 2 (1) Part I [electronic resource].

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In: Journal of Biological Chemistry and Environmental Sciences 2007.v.2(1)ISummary: The present study dealing with the effect of profenofos on subchronic toxicity test, including general toxicological (body weight changes and internal organ weights), and haematological indices (WBCs, RBCs, Hb, PCY, MCY, MCH and MCHC) and thyroid hormones analyses which supported by pathology of thyroid gland. Detectability of toxic effects of profenofos following adminstrate in drinking water at concentration of 22.25 (l/20LD₅₀) and 11.125 (l/40LD₅₀) ppm for 12 weeks in male albino rats. The results revealed a significant decrease in body weight gain, thyroxin (T4), Tri-iodothyronine (T3), white blood cells (WBCs), mean corpuscular haemoglobin (MCH) and mean corpuscular haemoglobin concentration (MCHC), while significant increase in red blood cells (RBCs), haemoglobin concentration, packed cell volume (PCY) and mean corpuscular volume (MCY). On the other hand no significant changes in the weights of liver, kidney, spleen, lung, heart and brain of male albino rats was recorded. Histopathological examination showed that, atrophy and colloid free lumen were observed in few acini of thyroid gland in male albino rats.

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The present study dealing with the effect of profenofos on subchronic toxicity test, including general toxicological (body weight changes and internal organ weights), and haematological indices (WBCs, RBCs, Hb, PCY, MCY, MCH and MCHC) and thyroid hormones analyses which supported by pathology of thyroid gland. Detectability of toxic effects of profenofos following adminstrate in drinking water at concentration of 22.25 (l/20LD₅₀) and 11.125 (l/40LD₅₀) ppm for 12 weeks in male albino rats. The results revealed a significant decrease in body weight gain, thyroxin (T4), Tri-iodothyronine (T3), white blood cells (WBCs), mean corpuscular haemoglobin (MCH) and mean corpuscular haemoglobin concentration (MCHC), while significant increase in red blood cells (RBCs), haemoglobin concentration, packed cell volume (PCY) and mean corpuscular volume (MCY). On the other hand no significant changes in the weights of liver, kidney, spleen, lung, heart and brain of male albino rats was recorded. Histopathological examination showed that, atrophy and colloid free lumen were observed in few acini of thyroid gland in male albino rats.

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