Protective effects of a combination of vitamins E and C plus selenium against the diniconazole toxicity in male albino rats [electronic resource].

Includes reference.

The present study is concerned with the involvement of influence of a combination of vitamins E and C plus Selenium (Se) (at Recommended Daily Allowance, US-RDA) in aemeliorating the toxic effects of diniconazole treatment in male albino rats. Following oral administration of diniconazole to rats in dosage of 22mg/kg B.Wt, (at dose represent I1/10 of oral LD₅₀) there was haematological changes, and hepatic lipid peroxidation, along with elevating of serum ALT activity (alanine aminotransferase) and an inhibition of AST (aspartate aminotransferase) and ALP activity (alkaline phosphatase), as well as a marked disturbance in the lipid metabolism of diniconazole-treated rats. Also, there was impairs in the kidney and thyroid function. But when supplemented rats with a combination of vitamins E and C plus selenium and then treated with diniconazole an improving in haematological findings was observed and biochemical alterations of liver enzymes and kidney function are missing. Also, the hepatic lipid peroxidation was suppressed, in addition to lowered serum total and low density lipoprotein cholesterol (TC & LDL-C) concentrations, with elevating level of hight density lipoprotein - Cholesterol (HDL-e), however, this combination succeed to improve the thyroid hormones metabolism especially, T₃ (Triiodothyronine) production.

Summary in Arabic.

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