Effect of chlorpyrifosmethyl on the foetuses and thyroid gland in albino rats [electronic resource].
Language: English Summary language: Arabic Description: p.277-296Other title:- تأثير مركب الكلوربيريفوس-ميثيل على الأجنة والغدة الدرقية في الفئران البيضاء [Added title page title]
- Journal of biological chemistry and environmental sciences, 2007 v. 2 (2) Part II [electronic resource].
Includes reference.
Chlorpyrifos-methyl (Reldan) is an organophosphorus compound widely used as insecticide and acaricide. The spread use of pesticide and occupational exposure to pollutants are usually connected with serious problems of pollution and health hazards. As the many potential hazardous of such chemicals, female reproductive toxicity, foetotoxicity, teratogenicity and dysfunction of thyroid gland are the special concern. The present study was initiated to study the teratogenic effects of chlorpyrifos-methyl and effect on thyroid function. The median lethal dose (LDso) of tested material to both males and females were 2189.27 and 1743.45mglkg b.wt., respectively. The teratogenic effects of chlorpyrifos-methyl to pregnant rats during the organogenesis period with 8.67 and 34.87 mglkg b.wt. reduced the number of corpora lutea, the number of implantation sites, the number of alive foetuses, sex ratio, mean foetal weight and mean weight of placenta. The results showed increase in the number of corpora lutea per litter, the number of early and late-resorption sites, percent pre- and post-implantation loss and percent post-implantation death. Visceral examination of foetuses showed anaphthalmia, asymmetric cerebral hemispheres, split thymus, distended urinary bladder with urine, hydroureter and dilated ureter. The most common skeletal malformations were incomplete ossification of the skull, wavy ribs, shorting ribs, absence one or more of stembrae and absence of digits of fore and hind limbs. Administration of chlorpyrifos-methyl showed a non significant reduction in total thyroxine and triiodo-thyroxine in all treatment except after 90th day with high dose, which showed increasing effect. Microscopically, thyroid gland in rats treated with chlorpyrifosmethyl showed atrophy and necrosis in most of the acini while other acini had no colloid material in their lumen after 90th day of treatments and after recovery period at low dose. But the high dose showed active acini with colloid material in their lumen after recovery period.
Summary in Arabic.
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