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Antitoxicant effects against CCl4-induced liver damage of ripe fruits ethanolic extract of black nightshades [electronic resource].

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Shallan, M.A

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Language: English Summary language: Arabic Description: p.181-205Other title:

تأثيرات المستخلص الكحولي لثمر عنب الديب المضادة لسمية رابع كلوريد الكربون المسبب لتليف انسجة الكبد.‪ [Added title page title]

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Journal of biological chemistry and environmental sciences, 2008 v. 3 (4) Part I [electronic resource].

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In: Journal of Biological Chemistry and Environmental Sciences 2008.v.3(4)ISummary: The present investigation was undertaken to study different biological activities of ripe fruits ethanolic extract of Solanum nigrum L. (Black nightshades). Tow kinds of experiments were taken off (antioxidants and hepatoprotective experiments), The results showed that crude ethanolic extract of black nightshades ripe fruits has a strong antioxidant activity as showed by DPPH assay, nitric oxide scavenging assay, total reducing power assay, Fenton's reaction assay and total antioxidant capacity assay. Finally, the extract showed a valuable effects as hepatoprotective agent in vivo in liver damage of CCl4-treated rats represented by improvements serum total protein, albumin, globulin and remarkable reduce the activity of OPT, OOT and ALP as well as bilirubin and uric acid but urea unchanged in serum. Collectively, ethanolic extract of black nightshades ripe fruits may use effectively to treat liver and kidney disease and liver damage prevention agent.

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The present investigation was undertaken to study different biological activities of ripe fruits ethanolic extract of Solanum nigrum L. (Black nightshades). Tow kinds of experiments were taken off (antioxidants and hepatoprotective experiments), The results showed that crude ethanolic extract of black nightshades ripe fruits has a strong antioxidant activity as showed by DPPH assay, nitric oxide scavenging assay, total reducing power assay, Fenton's reaction assay and total antioxidant capacity assay. Finally, the extract showed a valuable effects as hepatoprotective agent in vivo in liver damage of CCl4-treated rats represented by improvements serum total protein, albumin, globulin and remarkable reduce the activity of OPT, OOT and ALP as well as bilirubin and uric acid but urea unchanged in serum. Collectively, ethanolic extract of black nightshades ripe fruits may use effectively to treat liver and kidney disease and liver damage prevention agent.

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