Reduction of the hezared influences of dimethoate by guava antioxidant on body growth rate and blood constituents of albino rats [electronic resource].

By: Language: English Summary language: Arabic Description: p.343-362Other title:
  • خفض التأثيرات الضارة لمبيد الدايمثويت على نمو الجسم ومكونات الدم باستخدام الجوافة كمضاد للأكسدة [Added title page title]
Uniform titles:
  • Journal of biological chemistry and environmental sciences, 2008 v. 3 (4) Part II [electronic resource].
Subject(s): Online resources: In: Journal of Biological Chemistry and Environmental Sciences 2008.v.3(4)IISummary: The experiments to be reported here were focused on the effect of dimethoate in technical and formulated forms at sublethal dose of 1/20 of the LD₅₀ as well as the antioxidant effects of guava diet to reduce the pesticide toxicity on blood fractions, and body growth rate of male albino rats. Treatments of the pesticides were applied orally or dermally every two consecutive days for three months and the dried antioxidant agent (20% of the diet) was mixed with normal diet and fed ad libitum to rats. The influences of both forms of the pesticide and guava diet on body weight gain as well as RBCs and WBCs count, also the contents of blood hemoglobin, bilirubin, plasma soluble protein, thyroid gland hormones and ilk activity of acetylcholinesterase acid, alkaline phosphtatase and transaminases (GOT and GPT) of plasma were investigated. Body weight gain of male albino rats ingested technical or formulated form of dimethoate was lower than that of normal healthy animal and the level of feed efficiency was decreased but the ratio of liver weight/body weight was incrased at normal control. Moreover, both forms of the insecticide showed considerable elevation in all studied parameters in comparison with the control except cholinesterase activity, total hemoglobin level and RBCs count. These increases and decreases were more in case of formulated dimethoate than that of the technica1 form; also orally ingestions were more effective than derrnally treatment relative to control. Guava (as antioxidant agent) feeding to dimethoate ingestedrats improved the disturbances of the studied pesticide in the experimental animals. Metabolism guava treatment elevated total hemoglobin content and increased RBCs count as well as stimulated cholinesterase activity of dimethoate intoxicated rats. In contrast, activity of GOT and GPT as well as acid and alkaline posphatose activity was inhibited, but total soluble protein, T3, T4 and total c, bilirubin content was normalized by feeding on guava as antioxidant treatment in the dimethoate intoxicated groups. In addition, body weight gain and feed efficiency as well as liver weight also improved in the intoxicated animals by the guava treatment as antioxidant. It means that dimethoat produced disturbance in animal metabolism but guava (antioxidant) treated this dimthoate toxicity and showed the ability of the fruit to improve the toxic effect of the pesticide, which reduced the disturbance of dimethoate in animal metabolism.
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The experiments to be reported here were focused on the effect of dimethoate in technical and formulated forms at sublethal dose of 1/20 of the LD₅₀ as well as the antioxidant effects of guava diet to reduce the pesticide toxicity on blood fractions, and body growth rate of male albino rats. Treatments of the pesticides were applied orally or dermally every two consecutive days for three months and the dried antioxidant agent (20% of the diet) was mixed with normal diet and fed ad libitum to rats. The influences of both forms of the pesticide and guava diet on body weight gain as well as RBCs and WBCs count, also the contents of blood hemoglobin, bilirubin, plasma soluble protein, thyroid gland hormones and ilk activity of acetylcholinesterase acid, alkaline phosphtatase and transaminases (GOT and GPT) of plasma were investigated. Body weight gain of male albino rats ingested technical or formulated form of dimethoate was lower than that of normal healthy animal and the level of feed efficiency was decreased but the ratio of liver weight/body weight was incrased at normal control. Moreover, both forms of the insecticide showed considerable elevation in all studied parameters in comparison with the control except cholinesterase activity, total hemoglobin level and RBCs count. These increases and decreases were more in case of formulated dimethoate than that of the technica1 form; also orally ingestions were more effective than derrnally treatment relative to control. Guava (as antioxidant agent) feeding to dimethoate ingestedrats improved the disturbances of the studied pesticide in the experimental animals. Metabolism guava treatment elevated total hemoglobin content and increased RBCs count as well as stimulated cholinesterase activity of dimethoate intoxicated rats. In contrast, activity of GOT and GPT as well as acid and alkaline posphatose activity was inhibited, but total soluble protein, T3, T4 and total c, bilirubin content was normalized by feeding on guava as antioxidant treatment in the dimethoate intoxicated groups. In addition, body weight gain and feed efficiency as well as liver weight also improved in the intoxicated animals by the guava treatment as antioxidant. It means that dimethoat produced disturbance in animal metabolism but guava (antioxidant) treated this dimthoate toxicity and showed the ability of the fruit to improve the toxic effect of the pesticide, which reduced the disturbance of dimethoate in animal metabolism.

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