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Studies on evaluation of inactivated lyophilized Equine Influenza vaccine in Egypt [electronic resource].

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Saad, M. A

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Language: English Summary language: Arabic Description: p.485-495Other title:

دراسات علي معايرة لقاح انفلونزا الخيول المجفد في مصر [Added title page title]

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Veterinary medical journal, 2009 v.57 (3), Part 2 [electronic resource]:

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In: Veterinary Medical Journal 2009.v.57(3)Summary: Two batches of egg adapted monovalent inactivated freeze dried equine influenza vaccine (EIV) were evaluated. There was no abnormal appearance of the freezed disc, prepared from locally isolated strains. The efficacy was tested by lab animal (Guinea pigs) and target animal (horse). The vaccine proved to be safe and potent for both guinea pigs and horses. The mean haemagglutination inhibition (HI) antibodies of the vaccine reconstituted in DEAE-Dextran solution (as a solvent and adjuvant) were 120.4 and 153.7 in G. pigs, 179.2 and 230.4 in horses for the two batches of vaccine respectively. The keeping quality of the local prepared vaccine was studied. Shelf validity was stable at 4°C for one year, could be kept at -20°C for 3 years and 10 months at 40°C.

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Two batches of egg adapted monovalent inactivated freeze dried equine influenza vaccine (EIV) were evaluated. There was no abnormal appearance of the freezed disc, prepared from locally isolated strains. The efficacy was tested by lab animal (Guinea pigs) and target animal (horse). The vaccine proved to be safe and potent for both guinea pigs and horses. The mean haemagglutination inhibition (HI) antibodies of the vaccine reconstituted in DEAE-Dextran solution (as a solvent and adjuvant) were 120.4 and 153.7 in G. pigs, 179.2 and 230.4 in horses for the two batches of vaccine respectively. The keeping quality of the local prepared vaccine was studied. Shelf validity was stable at 4°C for one year, could be kept at -20°C for 3 years and 10 months at 40°C.

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