Oral intoxication of balaldi rabbits with metalaxyl, fungfcide. [electronic resource].

Includes references.

Several pesticides are widely employed in agriculture. The purpose of this study was to asses the oral toxicity of commonly used systemic fungicide, metalaxyl , which used on a wide range of crops in several countries including Egypt.This study was carried out on: 15 female baladi rabbits which divided into three groups, one of them kept as control administered corn oil alone , the second group orally administered with 1110 LD50 of metalaxyl twice weekly for 4 months. The third group was fed lettuce, (previously sprayed with metalaxyl for 3 days) for 4 months concurrently with dry ration. A, statistically significant decrease of hody weight in both treated groups. Biochemical analysis revealed an increase in serum transaminases (AST & ALT), serum lactate dehydrogenase (LDH) ,creatinine phosphokinase (CPK), u"rea and creatinine in hoth metalaxyl treated rabbits. Metalaxyl residues were higher in the muscle and liver of orally treated group while wasn't detected in the rabbit muscle after feeding conversely their liver contained metalaxyl . liver ,kidney and heart showed histopathological lesions of both treated groups. Thus, metalaxyl induced adverse health effects in baladi rabbits either after feeding or after, oral administration.

Summary in Arabic.

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