Hematological, biochemical and antioxidant system alteration in dermatophytosis in claves [electronic resource].

Includes references.

Dermatophytosis is a skin disease of worldwide distribution and responsible for high economic losses in cattle. It is exclusively caused by Trichophyton verrucosum. Tencross- bred calves, 10 - 12 months old, suffering from skin lesions (alopecia and circular circumscribed grayish-white crusty raised foci which mostly found on the head, external ears and neck) and ten healthy control calves were obtained from a private farm in Gharbia governorate. Mycological examination of skin scrapings and hairs from lesions of the affected calves revealed Trichophyton verrucosum to be the etiological agent. Blood and serum samples were collected from both groups for hematological examinations, serum biochemical analysis and evaluation of the antioxidant system. Results of the present work declared that dermatophytosis elicited a significant decrease in the red blood cell count, hemoglobin concentration and packed cell volume. Moreover, the disease produced leukocytosis neutropenia and lymphocytosis in addition to non significant change in the monocytes, eosinophils and basophiles. A significant increase in the adenosine deaminase (ADA), aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH) and gamma glutamyl transferase (GGT) reflected the effect of dermatophytosis on the liver function. Evaluation of the antioxidant parameters in affected calves revealed a significant increase in the malonedialdehyde (MDA) and nitric oxide (NO) associated with a significant decrease in the reduced glutathione (GSH) and zinc levels suggesting a possible relationship between the antioxidant system, oxidative stress, lipid peroxidation and dermatophytosis. Moreover, dermatophytosis provoked a significant increase in the serum total sialic acid (TSA) and lipid - bound sialic acid (LBSA) as markers of inflammation and injury in calves. It could be concluded that dermatophytosis caused a significant hematological, serum biochemical and antioxidant system alterations. Moreover, it is recommended to use antioxidants, as supportive treatment for dermatophytosis.

Summary in Arabic.

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