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Pathological and biochemical studies on the adverse effects of phenylbutazone administration in draft horses [electronic resource].

By:

Hussein,S.Hussein

Contributor(s):

El-Ashkerb, Maged. R

Language: English Summary language: Arabic Description: p.148-160Other title:

دراسات باثولوجية وبيوكميائية على التأثير السيئ لاستخدام الفينايل بيوتازون فى خيول الجر [Added title page title]

Uniform titles:

Zagazig veterinary journal, 2010 v. 38 (1) [electronic resource].

Subject(s):

Online resources:

Full Text Article.

In: Zagazig Veterinary Journal 2010.v.38(1)Summary: Phenylbutazone (PBl) is the most commonly used non-steroidal anti-inflammatory drugs (NSAlDs) in equine. Despite its beneficial effects, its misuse can result in deleterious findings including gastric and colonic ulceration and renal failure. The present study describes the lesions, hematological findings and biochemical profile in draft horses suffering orthopedic diseases and injected with PBl. Fifty-five native breed draft horses of both sexes (forty diseased and fifteen control) were clinically investigated during the period from October 2006 to December 2008. The treated horses were categorized into survivors gp.1 and nonsurvivors gp.2. Anemia, increased ALT, AST, urea and creatinine levels were noticed in both groups. The oxidative stress markers showed significantly elevated MDA and NO. Meanwhile, the GSH and SOD levels were significantly decreased.

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Phenylbutazone (PBl) is the most commonly used non-steroidal anti-inflammatory drugs (NSAlDs) in equine. Despite its beneficial effects, its misuse can result in deleterious findings including gastric and colonic ulceration and renal failure. The present study describes the lesions, hematological findings and biochemical profile in draft horses suffering orthopedic diseases and injected with PBl. Fifty-five native breed draft horses of both sexes (forty diseased and fifteen control) were clinically investigated during the period from October 2006 to December 2008. The treated horses were categorized into survivors gp.1 and nonsurvivors gp.2. Anemia, increased ALT, AST, urea and creatinine levels were noticed in both groups. The oxidative stress markers showed significantly elevated MDA and NO. Meanwhile, the GSH and SOD levels were significantly decreased.

Summary in Arabic.

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