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Studies on potential activity of amantadine on rift valley fever virus [electronic resource].

By:

Said, Taradi Abdel Fatah

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Language: English Summary language: Arabic Description: P. 92-98Other title:

دراسات لمعرفة تأثير نشاط الأمنتادين على فيروس حمى الوادى المتصدع [Added title page title]

Uniform titles:

Zagazig veterinary journal, 2008 v. 36 (3) [electronic resource].

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In: Zagazig Veterinary Journal 2008.v.36(3)Summary: Evaluation of the antiviral activity of Amantadine Hydrochloride (AH) against Rift Valley Fever virus (RVFV) was performed in BHK cells (monolayer and cell suspension), baby, adult mice and sheep. AH had cytotoxic effect on BHK cell suspension, while it had 50% cytotoxicity on BHK monolayer at conc. of 3 mg/ml and no cytotoxic effect on baby mice till 5mg/ml. AH stop the replication of RVFV when inoculated at the same time and before inoculation of RVFV on BHK monolayer cells at concentration of 200ug/ml. Using AH before and at the same time with RVFV inoculation in adult mice cause high protection (100%), while using AH after 24, 48 and 72 hours of RVFV inoculation in adult mice leading to 90, 60 and 20% protection respectively_ In sheep using the therapeutic dose of AH before and at the same time with RVFV ,infection showed no elevation of body temperature, while after 24 and 48 hrs it minimize the virus titer in sheep sera.

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Evaluation of the antiviral activity of Amantadine Hydrochloride (AH) against Rift Valley Fever virus (RVFV) was performed in BHK cells (monolayer and cell suspension), baby, adult mice and sheep. AH had cytotoxic effect on BHK cell suspension, while it had 50% cytotoxicity on BHK monolayer at conc. of 3 mg/ml and no cytotoxic effect on baby mice till 5mg/ml. AH stop the replication of RVFV when inoculated at the same time and before inoculation of RVFV on BHK monolayer cells at concentration of 200ug/ml. Using AH before and at the same time with RVFV inoculation in adult mice cause high protection (100%), while using AH after 24, 48 and 72 hours of RVFV inoculation in adult mice leading to 90, 60 and 20% protection respectively_ In sheep using the therapeutic dose of AH before and at the same time with RVFV ,infection showed no elevation of body temperature, while after 24 and 48 hrs it minimize the virus titer in sheep sera.

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