Clinicopathological studies on the effect of some bacterial infection in rabbits [electronic resource].

Includes references.

The present investigation was carried out on experimentally infected rabbits which obtained from the Animal House, Faculty of Veterinary Medicine, Zagazig University. A total of 45 white New Zealand rabbits apparently healthy, 0.5-0.75 kg body weight and one month age were used. The rabbits were divided into 4 groups. Group 1 (15) were kept as control. Group 2 (10) was dosed orally with 1.37ml of cooked meat medium(1X10⁹ microorganism/Kg body weight) of C.perfringens type A in 5ml sodium bicarbonate 10%. Group 3 (10) was dosed orally with 5ml bacterial suspension (normal saline) containing (5 X10⁷CFU) of E.coli . Group 4(10) was dosed orally with 1.37ml of cooked meat medium in 5ml sodium bicarbonate 10% (lX109 microorganism/Kg body weight) of C.perfringens type A and 5ml bacterial suspension (normal saline) containing (5 X107 CFU) of E.coli. Whole blood and serum samples were collected after 6hours, land 2weeks post infection. Clinical examination of the experimentally infected rabbits revealed depression, dullness, browen watery diarrhea and bloated abdomen and ascitis Haematological examination revealed a significant changes in the erythrocytic and leukocytic parameters 6hours, land 2weeks post infection. Biochemical analysis of the same groups revealed a significant changes in the AST,ALT, ALP, total protein, albumin ,globulin, total, direct and indirect bilirubin, creatinine,Ca,P and Na. It could be concluded that the rabbit infection with Clostridium perjringens type A and E.coli adversely affected the hepatic and renal functions.

Summary in Arabic.

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