Trial to increase the duration of neutralizing antibodies in cattle vaccinated with inactivated FMD vaccine [electronic resource].

Includes references.

Inactivated FMD vaccine is weakly immunogenic and multiple vaccinations at four-month intervals are necessary for the prevention of the disease. Our res91ts revealed that in cyclophosphamide treated animals, the antibody titers remained pro-tecting up to 35 weeks post vaccination ,while in non treated group, the animals became suscepti¬ble to infection 19 weeks post vaccination. So, it i~ possible to il1crease the duration of neutralizing antibodies in serum when a low single dose of cy-clophosphamide is administered four days before vaccination with aluminum hydroxide-saponin FMD vaccine and this will increase the intervals between vaccinations and decrease the commer-cialization costs of vaccination programs.

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