Efficacy and persistence of methoxyfenozide against the cotton leafworm Spodoptera littoralls (Boisd.) (Lepidoptera : Noctuidae) [electronic resource].

Includes references.

Many compounds are known to interfere with insect development, in particular with larval ecdysis. Ecdysone receptor agonists or moulting accelerating compounds (MACs) are non-steroidal ecdysone analogs and mimic the natural function of the endogenous moulting hormone 20-hydroxy-ecdysone. MACs bind to ecdysone receptor-ultraspiracle protein hetcrodimer complexes. This ligandhcterodimer complex then transactivates a cascade of genes by binding to a DNA ecdysone response element initiating molting. Chemically MACs are described as substituted dibenzoylhydrazines directly acting on ecdysone receptors (Nauen and Bretschneider, 2002). Methoxyfenozide is an insect growth regulator that acts as an agonist of 20-hydroxyecdysone, a key hormone in the molting process (Wing. 1988). Methoxyfenozide (RH-2485) is the latest compound in this class to be developed commercially and is the most potent analog to date against larval Lepidoptera (Ishaaya el al. 1995; Le ef al. 1996; Trisyono and Chippendale1997 and Smagghe el al., 1999). The first sales of methoxyfenozide occurred in 1999, and the first full registrations in the United States were granted for cotton and pome fruits in 2000.

1