Efficacy of cyclohexane-diamine-tetraacetic acid (cdta) in treatment of aluminum chloride toxicity in rabbits [electronic resource].

Includes references.

ABSTRACT Toxic effects of AIC13 in rabbits with reference to the efficacy of cyclohexanediaminetetra acetic acid (COTA) in its treatment were evaluated. Forty male adult New Zealand white rabbits were divided into four groups (n= 10). The first group was received only distilled water and served as control. The second group was dosed 20 mg AIC13/kg bw orally via drinking water for 3 months. The third group was dosed 20 mg AICh /kg bw orally via drinking water plus 4.2 mmol COT A/kg bw intraperitoneal (i.p.) daily for 3 months. The fourth group was dosed 20 mg AICI3/kg bw orally via drinking water for 3 months, then AICI3 administration was stopped and the animals treated with 4.2 mmol CDTA /kg bw i.p. daily for another 3 months. At the end of the experiment, blood samples were collected for RBCs, WBCs and differential leucocytic counts, HemobJobin (Hb), packed cell volume (PCV), mean corpuscular volume (MCV) and mean corpusclllar hemoglobin concentration (MCHC). Serum samples were obtained for creatinine. urea, uric acid, glucose, AP, AST, AL T, total protein, albumin, globulin, A/G ratio, triglycerides, lactate dehydrogenase (LDH) cholesterol, Aluminum, Copper, iron, zinc, calcium and phosphorus assay. Results revealed significant decrease in RBCs, WBCs, PCV, Hb and MCHC in group II and slightly decrease in group IV while group III showed no significant difference compared with group I. Increase the number of neutrophils. eosinophils and monocytes in group II followed by groups IV and III while basophils and lymphocytes took an opposite manner. Significant increase in creatinine. urea, uric acid. AP, AL T, AST, triglycerides and LDH concentrations in group II followed by group IV while group III showed no significant difference compared with control. Significant decrease in glucose. cholesterol and total protein and its fractions (albumin and Globulin) in group II and III. Significant increase in aluminum and iron in-group II and IV while in-group III there is no different from contro. (group I). Decreased concentration of Cu. Zn. Ca and P in-groups II and IV while group III show no significant difference. The use of Cyclohexanediamineteraacetic acid (CDTA) in alleviating AIC13 toxicity was effective firstly in the third group followed by group IV. The use of CDTA in treatment of aluminum toxicity was most effective when used as prophylactic or when administered in the same time with aluminum as appeared clearly in the third group than it administered post aluminum exposure.

Summary in Arabic.

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