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Genotoxic and cytotoxic biomarkers of aflatoxin B1 and the use of curcumin as antidotal therapy [electronic resource].

By:

El-Hady, Kawther A

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Language: English Summary language: Arabic Description: p.86-102Other title:

الدلالات الجينية والخلوية للتسمم بالافلاتوكسين ب1 ودور الكوركيومين كترياق علاجى [Added title page title]

Uniform titles:

Zagazig veterinary journal, 2011 v. 39 (1) [electronic resource].

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In: Zagazig Veterinary Journal 2011.v.39(1)Summary: This study was earned out to spot light on the different biomarkers caused by aflatoxin B1 oxidative damage, in order to get an early diagnosis, and study the effect of curcumin as a model used as an antidotal therapy to reduce or even ameliorate the oxidative damage induced by aflatoxin B1. Forty apparently healthy male adult albino rats weighing 120-150 gm were divided into four equal groups, the 1st group was orally administered 250 ug/kg Body weight aflatoxin B1 using stomach gavage, the 2nd group was orally administered 250 ug/kg body weight in combination with 200 mg/kg body weight Curcumin, the 3rd group was orally administered 200 mg/kg body weight Curcumin, while the fourth group was administered distilled water and kept as negative control group.

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This study was earned out to spot light on the different biomarkers caused by aflatoxin B1 oxidative damage, in order to get an early diagnosis, and study the effect of curcumin as a model used as an antidotal therapy to reduce or even ameliorate the oxidative damage induced by aflatoxin B1. Forty apparently healthy male adult albino rats weighing 120-150 gm were divided into four equal groups, the 1st group was orally administered 250 ug/kg Body weight aflatoxin B1 using stomach gavage, the 2nd group was orally administered 250 ug/kg body weight in combination with 200 mg/kg body weight Curcumin, the 3rd group was orally administered 200 mg/kg body weight Curcumin, while the fourth group was administered distilled water and kept as negative control group.

Summary in Arabic.

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