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Determination of genotоxic effects of some food additives on some human cancer cells by flow cytometry analysis [electronic resource].

By:

Rashad, Shimaa E

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Language: English Summary language: Arabic Description: p. 329-343Uniform titles:

Egyptian journal of genetics and cytology, 2018. v. 47 (2) [electronic resource].

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Online resources:

Full Text Article.

In: Egyptian Journal of Genetics and Cytology 2018.v.47(2)Summary: Any substance added to food is apt to change any of its attributes from the beginning of the production phase and ending to the consumer, it is added in or-der to improve preservation or sensory qualities or reduction of exposing con-sumers to poisoning and other health haz-ards. Cann et al. (2007) some investiga-tions aimed at determining the effect of mono sodium glutamate (MSG) on body organs showed that it inflicted DNA dam-age at all concentrations in isolated human lymphocytes after 1 h in vitro exposure. It was demonstrated that MSG is genotoxic to the human peripheral blood lympho-cytes (Ataseven et al., 2016). Osfor et al. (1997) indicated that kidney, liver, brain, and heart weight significantly increased in rats treated with MSG. MSG in high doses produced neuroendocrine abnormal-ities and neuronal degeneration (Moreno, 2005), and oxidative damage in different organs (Farmobi and Onyema, 2006; Pavlovic et al., 2007). Furthermore, glu-tamate in high concentrations, particularly in postnatal period, could act as a neuro-toxin (excitotoxin) (Eweka et al., 2011).

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Articles	Main	ART EJGC V47 No2 13 (Browse shelf(Opens below))	Available

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Includes references.

Any substance added to food is apt to change any of its attributes from the beginning of the production phase and ending to the consumer, it is added in or-der to improve preservation or sensory qualities or reduction of exposing con-sumers to poisoning and other health haz-ards.
Cann et al. (2007) some investiga-tions aimed at determining the effect of mono sodium glutamate (MSG) on body organs showed that it inflicted DNA dam-age at all concentrations in isolated human lymphocytes after 1 h in vitro exposure. It was demonstrated that MSG is genotoxic to the human peripheral blood lympho-cytes (Ataseven et al., 2016). Osfor et al. (1997) indicated that kidney, liver, brain, and heart weight significantly increased in rats treated with MSG. MSG in high doses produced neuroendocrine abnormal-ities and neuronal degeneration (Moreno, 2005), and oxidative damage in different organs (Farmobi and Onyema, 2006; Pavlovic et al., 2007). Furthermore, glu-tamate in high concentrations, particularly in postnatal period, could act as a neuro-toxin (excitotoxin) (Eweka et al., 2011).

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