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Experimental study for evaluation of antimicrobial activity of the aqueous garlic extract in treatment of arthritis in rabbits [electronic resource].

By:

Al-Talibi, Mohammad A

Language: English Summary language: Arabic Description: p.266-279Uniform titles:

Assiut veterinary medical journal, 2011 v. 57 (131) [electronic resource].

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In: Assiut Veterinary Medical Journal 2011.v.57(131)Summary: The study was conducted to evaluate the ability of Aqueous Garlic Extract (AGE) for inhibition the growth of Salmonella typhimurium as a probable cause of arthritis in rabbits in vitro and in vivo study. Results revealed that AGE (contain 201.2μg/ml allicin) have excellent antibacterial activity against this strain at 2:60% concentration. while the concentration ≥20% showed moderate activity, Moreover concentration of <20% show no effect in vitro. The in vivo study was explained the infectious dose of Salmonella typhimurium that induce arthritis in experimental animals was ≥ 1 x10⁵ C.F.U/ml when injected intrarticularly. Garlic extract was administrated to treat experimental induced arthritis for 5 days by using different doses subcutaneously. It have been shown that a dose rate of 100mg/kg B.W S.C were more effective and have no adverse effects. Some bacteriology, serology and hematological tests were used as indicators to confirm infection and evaluation of treatment in rabbits.

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The study was conducted to evaluate the ability of Aqueous Garlic Extract (AGE) for inhibition the growth of Salmonella typhimurium as a probable cause of arthritis in rabbits in vitro and in vivo study. Results revealed that AGE (contain 201.2μg/ml allicin) have excellent antibacterial activity against this strain at 2:60% concentration. while the concentration ≥20% showed moderate activity, Moreover concentration of <20% show no effect in vitro. The in vivo study was explained the infectious dose of Salmonella typhimurium that induce arthritis in experimental animals was ≥ 1 x10⁵ C.F.U/ml when injected intrarticularly. Garlic extract was administrated to treat experimental induced arthritis for 5 days by using different doses subcutaneously. It have been shown that a dose rate of 100mg/kg B.W S.C were more effective and have no adverse effects. Some bacteriology, serology and hematological tests were used as indicators to confirm infection and evaluation of treatment in rabbits.

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