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Role of ceramide in trandferrin receptor movement in the plane of the plasma membrane [electronic resource].

By:

Abdel-Shakor, A-B. M

Contributor(s):

Al-Awadhi, Rana

Language: English Summary language: Arabic Description: P. 17-35Other title:

دور السيراميد في حركة مستقبل الترانسفرين على سطح غشاء البلازما [Added title page title]

Uniform titles:

Assiut veterinary medical journal, 2010 v. 56 (124) [electronic resource].

Subject(s):

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Full Text Article.

In: Assiut Veterinary Medical Journal 2010.v.56(124)Summary: After ligation with transferring (Tf), transferring receptor (Tfr) is aggregated on cell surface in clathrin coated pits and then internalized into the cell. In the present work, the mechanism of (Tf/TfR) and the role of ceramide in this mechanism were studied. After Tf/TfR ligation, ceramide level on plasma membrane outer leaflet was temporarily elevated as clarified by immunocytochemical detection of cell surface ceramide in human "jurkat" T lymphoma cell line. Ceramide elevation was confirmed by diacylgelycerol kinase assay for biochemical ceramide measurement.

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After ligation with transferring (Tf), transferring receptor (Tfr) is aggregated on cell surface in clathrin coated pits and then internalized into the cell. In the present work, the mechanism of (Tf/TfR) and the role of ceramide in this mechanism were studied. After Tf/TfR ligation, ceramide level on plasma membrane outer leaflet was temporarily elevated as clarified by immunocytochemical detection of cell surface ceramide in human "jurkat" T lymphoma cell line. Ceramide elevation was confirmed by diacylgelycerol kinase assay for biochemical ceramide measurement.

Summary in Arabic.

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