A study on the role of tribulus terrestris in cadmium induced toxicity on some organs of adult male albino rats [electronic resource]
Language: English Summary language: Arabic Publication details: 2023Description: p. 209-228Other title:- دراسة عن دور تريبولوس تيريستريس في السمية الناتجة عن الكادميوم علي بعض أعضاء ذكور الجرذان البيضاء البالغة [Added title page title]
- Assiut veterinary medical journal, 2023 v. 69 (179) [electronic resource].
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Main | ART AVMJ V69 No179 18 (Browse shelf(Opens below)) | Available |
Includes bibliographic reference.
Cadmium (Cd) is a dangerous environmental pollutant that causes toxicity to humans and
animals even when exposed to a small amount as it is hard to expel from the body affecting
all body parts. Tribulus terrestris (Tt) is a natural herb used for its medicinal effects around
the world. This study directed to detect the possibility of Tt to protect from Cd toxicity in
adult male albino rats. Twenty-four rats were separated into four groups, each 6 rats: The
first group (C); served as a control without any treatments. Group (2) (Tt + Cd); administrated
daily by oral dose of Tt (5 mg/ kg b. wt. liquified in distilled water) for eight weeks then from
the start of the ninth week, they daily injected intraperitoneally with Cd (2 mg/kg b. wt.) for
eight days. Group (3) (Cd); injected with Cd only at the same dose for eight days. Group (4)
(Cd + Tt); firstly, injected with Cd at the same dose for eight days then on the ninth day they
had the same Tt dose for eight weeks. In this study, results clarified that Cd application
significantly decreased plasma SOD level and the time spent in the opened arms of the
elevated plus maze test while increased plasma levels of H2O2, CRP, IL-6, immunoreaction
of brain cleaved caspase-3 and the time spent in the closed arms of the elevated plus maze
test compared to control. Administration of Tt succeeded to increase SOD level and the time
spent in the opened arms of the elevated plus maze test; however, it reduced plasma levels of
H2O2, CRP, IL-6, immunoreaction of brain cleaved caspase-3 and the time spent in the closed
arms of the elevated plus maze test in comparison with Cd group. In conclusion, Tt is highly
protective for the brain from harmful Cd effects, referring to its antioxidant, anti inflammatory
and antiapoptotic properties.
Keywords: Tribulus terrestris, cadmium, brain, behavior, oxidative stress, cytokines, apoptosis, Caspase-3, histopathology
Summary in Arabic
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