Ultrastructural study on the hepatoprotective effect of selenium-loaded chitosan nanoparticles against silver nanoparticles-induced toxicity in the female albino rats [electronic resource].
Language: English Summary language: Arabic Publication details: 2023Description: p. 1 – 12Uniform titles:- Veterinary medical journal, 2023 v.69 (1) [electronic resource].
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Articles
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Main | ART VMJ V69 No1 1 (Browse shelf(Opens below)) | Available |
Includes references.
Silver nanoparticles (Ag-NPs) are increasingly used in industrial and biological
applications. There are growing worries regarding their toxicity to both humans and
animals. Selenium-loaded chitosan nanoparticles (CS-SeNPs) have strong antioxidant
properties via scavenging free radicals. The aim of this study is to assess the protective
effect of CS-SeNPs against Ag-NPs' damaging effects on the hepatic tissue of adult female
rats. Forty female albino rats were separated into four groups: group I (control) was given
distilled water (0.5 ml/kg), group II was administered Ag-NPs (100 mg/kg), group III was
co-exposed with Ag-NPs (100 mg/kg) and CS-SeNPs (0.5 mg/kg) and group IV received
only CS-SeNPs (0.5 mg/kg) daily by oral gavage. After 60 days, rats were euthanized, then
hepatic tissues were collected and fixed in 5% glutaraldehyde for transmission electron
microscopy. Exposure to Ag-NPs induced severe degeneration of the hepatocytes, in the
form of complete lysis and disappearance of the cytoplasmic organelles. While
supplementation with CS-SeNPs exhibited a partial disappearance of most degenerative
changes induced by Ag-NPs. In conclusion, Ag-NPs induce some destructive effects on
the hepatic tissue and CS-SeNPs can ameliorate most of these harmful effects.
Keywords: Silver nanoparticles; Selenium-loaded chitosan nanoparticles; Hepatotoxicity; Ultrastructure.
Summary in Arabic.
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