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Biochemical studies on ionic homeostasis in diabetic and insulin-treated albino rats [electronic resource].

By:

Attia, K. A

Contributor(s):

Abd El-Hamid, Safaa S

Language: English Summary language: Arabic Description: p.300-310Other title:

دراسات بيوكيميائية على التوازن الإيونى فى الفئران المصابة بمرض البول السكرى والمعالجة بالأنسولين.‪ [Added title page title]

Uniform titles:

Assiut veterinary medical journal, 2006 v. 52 (108) [electronic resource].

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In: Assiut Veterinary Medical Journal 2006.v.52(108)Summary: In the present study, copper, magnesium, calcium, sodium and potassium homeostasis as well as blood glucose and liver glycogen were investigated in untreated and treated diabetic rats. The ionic alterations in plasma and liver were concomittant with those fluctuations occurring in blood glucose and liver glycogen through all the periods of investigation. In treated rats, insulin injection was able to maintain, for a large extent, the ionic homeostasis. It seems that the endocrine imbalance was responsible for the alterations in both transport and metabolism of those ions. Also, it is possible that alterations in plasma and tissue levels of those ions may contribute to the development of liver complication.

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In the present study, copper, magnesium, calcium, sodium and potassium homeostasis as well as blood glucose and liver glycogen were investigated in untreated and treated diabetic rats. The ionic alterations in plasma and liver were concomittant with those fluctuations occurring in blood glucose and liver glycogen through all the periods of investigation. In treated rats, insulin injection was able to maintain, for a large extent, the ionic homeostasis. It seems that the endocrine imbalance was responsible for the alterations in both transport and metabolism of those ions. Also, it is possible that alterations in plasma and tissue levels of those ions may contribute to the development of liver complication.

Summary in Arabic.

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