The hepatoprotective and anti-fibrotic activities of freeze-dried saponin and tannin extracts on CCI4 - induced hepatotoxicity in rats [electronic resource].

Includes references.

Saponins of defatted soybean seeds and tannins of faba bean hulls were extracted, freeze-dried and the chemical composition was determined before and after extraction and freeze-drying. The hepatoprotective and anti-fibrotic activities of these freeze-dried extracts on carbon tetrachloride (CCI4)-induced hepatotoxicity on rats were evaluated. Repeated administration of CCI4 subcutaneously (S.C) on rats for 8 weeks significantly elevated serum enzymes activity assessted for liver function, Le., AST, AL T and ALP. Also, the same administration accumulated and deposited the hepatic collagen protein of rats. The altered chemical parameters and the accumulated and deposited collagen were significantly benefited by the both freeze-dried extracts administration per oraiiy (P.O). The results show that both freeze-dried saponin and tannin extracts have a hepatoprotective and anti-fibrotic activities against CCI-4- induced hepatotoxicity in rats, but the mechanism and the active compounds of these extracts require further studies.

Summary in Arabic.

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