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Cytotoxicity induced by alprazolam in rat vital organs [electronic resource].

By:

Abdelmajeed, Nadia A

Contributor(s):

Manaa, Amani M

Language: English Summary language: Arabic Description: p.131-146Other title:

السمية الخلوية التي يسببها ألبرازولام في الأجهزة للجرذان [Added title page title]

Uniform titles:

Mansoura Veterinary Medical Journal, 2009 v. 11 (2) [electronic resource].

Subject(s):

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Full Text Article.

In: Mansoura Veterinary Medical Journal 2009.v.11(2)Summary: The current study demonstrated the cytotoxic effects of alprazolam on the vital organs of rats. Animals were divided into two groups; G1: normal control (not received any drug), G2: alprazolam treated group. Alprazolam was ingested orally using a single dose of 1 mg/ 100gm body weight. The effects of this drug toxicity on different tissue vital organs tissues (liver, kidney and heart) were studied after 10, 20 and 30 days from drug administration. The results revealed that administration of alprazolam induces oxidative tissue damage indicated by significant increase in the activity of xanthine oxidase (XO) with concomitant elevated level of nitric oxide (NO) in liver, kidney and heart of alprazolam -treated rats in comparison with normal animals. The increment of such oxidative tissue damage markers was accompanied by increased malondialdehyde (MDA, index of lipid peroxidation) in kidney ,and decrease in adenosine triphosphatase (ATPase) and lactate dehdrogenase (LDH) activities in cardiac tissue. The oxidative tissue damage induced in liver in response to alprazolam ingestion was supported by a depletion in the activity of hepatic sorbitol dehydrogenase (SD) coupled with elevation in serum enzymes, aspartate aminotransferase (AST), alanine aminotransferase (ALT) and gamma-glutamyl transferase (GGT) ( indices of liver function ). Also the obvious increase of serum markers of kidney, creatinine and uric acid levels as well as the increase in serum marker enzyme of heart, creatine phosphokinase (CPK) in alprazolam treated animals versus normal ones, indicating cardiorenopathy. Moreover, investigation also revealed that ingestion of alprazolam to rats led to decreased level of hemoglobin (Hb) compared with normal animals The deteriorations in the biochemical results were severe in 20 and 30 days after the drug administration and documented by the histopathological pictures of the studied organs.

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The current study demonstrated the cytotoxic effects of alprazolam on the vital organs of rats. Animals were divided into two groups; G1: normal control (not received any drug), G2: alprazolam treated group. Alprazolam was ingested orally using a single dose of 1 mg/ 100gm body weight. The effects of this drug toxicity on different tissue vital organs tissues (liver, kidney and heart) were studied after 10, 20 and 30 days from drug administration. The results revealed that administration of alprazolam induces oxidative tissue damage indicated by significant increase in the activity of xanthine oxidase (XO) with concomitant elevated level of nitric oxide (NO) in liver, kidney and heart of alprazolam -treated rats in comparison with normal animals. The increment of such oxidative tissue damage markers was accompanied by increased malondialdehyde (MDA, index of lipid peroxidation) in kidney ,and decrease in adenosine triphosphatase (ATPase) and lactate dehdrogenase (LDH) activities in cardiac tissue. The oxidative tissue damage induced in liver in response to alprazolam ingestion was supported by a depletion in the activity of hepatic sorbitol dehydrogenase (SD) coupled with elevation in serum enzymes, aspartate aminotransferase (AST), alanine aminotransferase (ALT) and gamma-glutamyl transferase (GGT) ( indices of liver function ). Also the obvious increase of serum markers of kidney, creatinine and uric acid levels as well as the increase in serum marker enzyme of heart, creatine phosphokinase (CPK) in alprazolam treated animals versus normal ones, indicating cardiorenopathy. Moreover, investigation also revealed that ingestion of alprazolam to rats led to decreased level of hemoglobin (Hb) compared with normal animals The deteriorations in the biochemical results were severe in 20 and 30 days after the drug administration and documented by the histopathological pictures of the studied organs.

Summary in Arabic.

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