Nucleotide sequence of presenilin-1 cDNA fragment of Arabian camel, Camelus dromedarius [electronic resource].

Includes references.

The cDNA encoding camel presenilin-1 (PS1) fragment was cloned by reverse transcriptionpolymerase chain reaction (RT-peR) using primers homologous to conserved sequences of PS1 of human, rat, lemur and mouse. The cDNAfragment, 402 bp in size was well conserved andfound to be 79, 89, 91, 91 and 93% homologous to that of chicken, mouse, rat, lemur and human, respectively. The eDNA fragment encodes 130 amino acid protein fragment. The deduced amino acid sequence is also well conserved in various species, exhibiting 98% similarities with those of rat, lemur and Iwman homologues. This cDNA fragmelll is quite significalll as it is the most conserved portion or the PS1 in various animals and encodes four transmembrane regiollS (TM2, 3, 4, 5) of PS1. Moreover, more than 50% of the amino acid substitutions to which familiar Alzheimer's disease (FAD) have been linked are located in this region.

Summary in Arabic.

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