Pharmacological studies on some antibacterial drugs in fish [electronic resource].

Includes references.

The antibacterial activities of ciprofloxacin(CIP), florfenicol(FC) and oxytetracycline (OCT) were investigated either in-vitro and in-vivo against Aeromonas hydrophila in Clarias Lazera . The obtained results indicated that these drugs were effective in vitro against this microorganism with MIC 1.1 ,0.08 and 2.8 μg/ml for florfenicol , ciprofloxacin and oxytetracycline respectively . The in-vivo antibacterial activity of these drugs in their therapeutic doses showed a decline in mortality rates(%) and pathogenic clinical signs compared to that of infected non medicated group. The estimated hematological parameters showed that both ciprofloxacin and oxytetracycline caused significant decrease in all hematological parameters while florfenicol cause a slight decrease , and all these changes were reversible and returned to the normal range within 7 days of treatment . The effects of these drugs on the estimated biochemical parameters showed that, florfenicol induced non significant changes in all biochemical parameters compared to the control group, while significant changes were recorded between florfenicol treated group and that treated with either ciprofloxacin and oxytetracycline. There were also a significant changes between the infected non treated group compared to all other groups .

Summary in Arabic.

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