Histological and clinicopathological studies following partial hepatectomy in dogs [electronic resource].

Includes references.

This study was carried out to evaluate the state of the liver in dogs after partial hepatectomy by histopathological and clinicpathological examinatons. Fifteen healthy male dogs were used in this study and classified into equal three groups. Dogs of group (I) served as control and exposed to laparotomy, dogs of group (II) were used for partial hepatectomy of left lateral lobe while those of group (III) were subjected to partial hepatectomy of the whole left lobe. Blood samples were taken at 1st 2nd, 3rd, 4th, 6th and 8th weeks of surgery to determine: alanine aminotransferase aspartate aminotransferase, alkaline phosphatase and glucose. After the 8th weeks, the dogs were sacrificed to obtain the liver for the histopathological and histochemical examinations. Group (I) showed normalliver structure. Group (II, III) showed signs of regeneration where hypertrophy of the hepatocytes and increase number of binucleated cells were evident. The hepatocytes nuclei were at different stages of nuclear activities. There were newly formed bile duct. The glycogen level in the liver decreased after resection. The intensity of the reaction to acid phosphatase, alkaline phosphatase, ATPase and SDH increased after resection. In conclusion, after partial hepatectomy the hepatic tissue try restore its original size through regeneration of the hepatocytes. Key words: Histopathology, clinicpathology, heaptictomy, dog.

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