Pathological studies on the effects of some locust insecticides on rabbits [electronic resource].

Includes references.

Forty-five, New Zealand, rabbits of two months age were used to study the pathological effects of some locust insecticides (chloropyrifos and difIubenzuron) to evaluate the less toxic one. The rabbits were divided into 5equal groups. Gp.l was kept as untreated control. Gp. 2 treated with chloropyrifos(48%) in a dose of750 ppm ofthe diet. Gp.3 treated with chloropyrifos (48%) in a dose of 1500 ppm of the diet Gp. 4 treated with difIubenzuron in a dose of 8000 ppm of the diet. Gp. 5 treated with 16000 ppm difIubenzuron of the diet. Three rabbits from each group were necropsied 15, 30 and 45 days post-administration (PA). Specimens were collected from liver and kidneys and fixed in 10% neutral buffered formalin. Paraffin sections, 5µ thick, were prepared and stained with hematoxylin and eosin and examined microscopically. No clinical signs were recorded among rabbits of gps 2 and 4, Meanwhile rabbits of gps 3and 5 showed reduction in body weight 15 and 30 days PA besides salivation and lacrimation among rabbits of gp3 at 45 days PA . No mortalities were recorded in all groups throughout the experimental period. Grossly, the liver and kidneys at gps. 2, 3, 4 and 5 were large and dark red in color 15 and 30 days PA .The rabbits of gps. 3 and 5 showed enlarged and pale-yellow liver, 45 days PA. The liver was firm in some cases. The kidneys were enlarged and showed few grayish white foci, 1mm in diameter on its surface.

Summary in Arabic.

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