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Liver tumor promoting activity of butylated hydroxytoluene in C-MYC transgenic mouse model of liver cancer [electronic resource].

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Elalfy, M

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Language: English Summary language: Arabic Description: p.229-246Other title:

زيادة نشاط ماده البيتوليد هيدروكسى تولوين فى احداث سرطان الكبد فى الجرزان المعدله ورثيا والحاملة للجين ميك.‪ [Added title page title]

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Mansoura Veterinary Medical Journal, 2011 v. 13 (1) [electronic resource].

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In: Mansoura Veterinary Medical Journal 2011.v.13(1)Summary: Liver tumor promoting activity of butylated hydroxytoluene (BHT) is controversial. butylated hydroxytoluene (BHT) had previously reported to have a promoting and protective roles in occurrence of tumour formation but strain differences, the effect upon various carcinogens, paradoxical dose responses and mechanisms ofaction remain major questions in the toxicology of BHT. Here, we investigate the promoter activity of BHT in c-myc transgenc mouse model of liver cancer. It was found that BHT increase liver to body weight ratio especially at age of 4 month immediately after treatment when compared with non- transgenic control.

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Liver tumor promoting activity of butylated hydroxytoluene (BHT) is controversial. butylated hydroxytoluene (BHT) had previously reported to have a promoting and protective roles in occurrence of tumour formation but strain differences, the effect upon various carcinogens, paradoxical dose responses and mechanisms ofaction remain major questions in the toxicology of BHT. Here, we investigate the promoter activity of BHT in c-myc transgenc mouse model of liver cancer. It was found that BHT increase liver to body weight ratio especially at age of 4 month immediately after treatment when compared with non- transgenic control.

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