An introduction to clinical pharmacokinetics: models and software [electronic resource].

Includes references.

The appropriate administration of pharmacological agents to animals requires a detailed understanding of pharmacokinetics and pharmacodynamics (Figure I). This is because the clinical dosage regimen depends on how the body acts on the drug and its dosage formulation (pharmacokinetics) as well as t,he safety and efficacy of the drug (pharmacodynamics). Dosage regimens are designed to achieve therapeutic concentrations and maintain a therapeutic response, while miniinizing adverse side effects, expense, and promotion of antimicrobial resistance. This brief review has 2 main objectives: I) to present an overview of the basic processes of drug absorption, distribution and elimination and how these processes are quantified using different pharmacokinetic approaches; and 2) to identify computer software programs and web sites lhal are useful resources for veterinarians interested in clinical pharmacology and pharmacokinetics .

Summary in Arabic.

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