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Effect of acute gastoxine pesticide adminstration on some biochemical parameters in male white albino rats [electronic resource].

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Fouad, A. A

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Language: English Summary language: Arabic Description: p. 549-559Other title:

التأثير الحاد لتعاطي الجاستوكسين علي بعض القياسات الكيميائية الحيوية في ذكور فئران الالبينو البيضاء [Added title page title]

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Journal of biological chemistry and environmental sciences, 2010 v. 5 (4) Part (2) [electronic resource].

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In: Journal of Biological Chemistry and Environmental Sciences 2010.v.5(4)Part(2)Summary: The objective of the present study was to examine the effects of gastoxine (AlP), pesticide as organophosphorus on malondialdehyde (MDA), acetylcholinesterase (AChE), total glutathione (GSH), urea and creatinine of male albino rats. A total of 45 male white rats were assigned into three groups with fifteen animals per group (n=15). The first group served as control group and was given only corn oil (vehicle) while the other two groups were given gastoxine at Acceptable Daily Intake dose (ADI, 0.004 mg /kg B.W/ day) and No Observed Adverse Effect Level dose (NOAEL, 0.40 mg/ kg B.W/ day) was given to male white rats which weighted 200 ± 20g for 4 weeks. The results exhibited significant inhibition on acetylcholinesterase activity. No significant differences in MDA levels were noted in gastoxine at both doses in treated rats. Also significant increase in the (GSH) level were obtained in treated rats with gastoxine at ADI dose. On the other hand, the total GSH level showed high significant decrease in gastoxine (NOAEL)-treated rats and remarkable elevation of creatinine and urea were noted in gastoxine for rats exposed at both doses. Key words: Organophosphorus (OPs), gastoxine (AlP), malondialdehyde (MDA), acetylcholinesterase (AChE) , total glutathione (GSH) .

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The objective of the present study was to examine the effects of gastoxine (AlP), pesticide as organophosphorus on malondialdehyde (MDA), acetylcholinesterase (AChE), total glutathione (GSH), urea and creatinine of male albino rats. A total of 45 male white rats were assigned into three groups with fifteen animals per group (n=15). The first group served as control group and was given only corn oil (vehicle) while the other two groups were given gastoxine at Acceptable Daily Intake dose (ADI, 0.004 mg /kg B.W/ day) and No Observed Adverse Effect Level dose (NOAEL, 0.40 mg/ kg B.W/ day) was given to male white rats which weighted 200 ± 20g for 4 weeks. The results exhibited significant inhibition on acetylcholinesterase activity. No significant differences in MDA levels were noted in gastoxine at both doses in treated rats. Also significant increase in the (GSH) level were obtained in treated rats with gastoxine at ADI dose. On the other hand, the total GSH level showed high significant decrease in gastoxine (NOAEL)-treated rats and remarkable elevation of creatinine and urea were noted in gastoxine for rats exposed at both doses. Key words: Organophosphorus (OPs), gastoxine (AlP), malondialdehyde (MDA), acetylcholinesterase (AChE) , total glutathione (GSH) .

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