Ultrasonographic, clinicopathological and histopathological renal changes associated with experimental use of phenylbutazone in dogs [electronic resource].

Includes references.

Fifteen apparently healthy, adult mongrel dogs of both sexes ranging from 9-14 kg live body weight were included in the present investigation. Animals were classified into three groups each had five dogs. The first group injected intramuscularly with phenylbutazone at dose rate of 15 mg/kg body weigpt (B.W) twice daily for 10 successive days and drinkiag.water ad libitum together with intravenous injection of 0.9% saline solution at dose rate of 30 cc/kg B.W. The second group received the same treatments, but without saline solution, while the third group received the same dose of phenylbutazone without saline solution but with restricted drinking water (200 cc/animal/ day).At the end of experiment, all animals in the three groups were evaluated clinically, ultrasonically and histopathologically. Except for the third group, dogs did not develop general clinical signs or specific renal abnormalities. Dogs of the third group develop signs of lethargy, dehydration at loss of body condition and the biochemical find ings confirmed these observations.

Summary in Arabic.

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