Cardioprotective effects of lagenaria sicessaria (molina)fruit juice against isoproterenol and carbon tetrachloride induced-myocardial infractionin albino rats [electronic resource].

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The present study was designed to evaluate the cardioprotective effects of Lagenaria siceraria fruit juice in carbon tetrachloride (CCl4) and isoproterenol (ISO)-induced Cardiotoxicity infraction. Rats injected with isoproterenol (85 mg/kg, s.c.) induced a significant decrease in total protein, catalase, GPx and HDL showed a significant increase in the levels of serum uric acid, Na, Ca, creatinine, urea, serum total cholesterol, triglycerides, LDL, GOT, GPT and A.LP. lsoproterenol and CC/4 injected rats also showed a significant when P s 0.05 increased incidence of DNA fragmentation and apoptosis which were evident in pups of isoproterenol and CCl4 injected. Treatment with L siceraria fruit juice (30 ml/kg/day, p.o.) and administration of isoproterenol and CCl4 showed a protective effect on altered biochemical and showed a marked amelioration in DNA. These findings indicate the cardioprotective effect of L. siceraria fruit juice in CCl4 and isoproterenol-induced myocardial infraction in rats.

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