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Pharmacokinetics of ciprofloxacin and its interaction with diclofenac after intravenous injection in healthy rabbits [electronic resource].

By:

Shaheen, H.M

Contributor(s):

El-Sheikh, M. W

Language: English Summary language: Arabic Description: p.189-209Uniform titles:

kafrelsheikh veterinary medical journal, 2011 v. 9 (1) [electronic resource].

Subject(s):

Online resources:

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In: Kafrelsheikh Veterinary Medical Journal 2011.v.9(1)Summary: The purpose ofthis study was to determine the pharmacokinetics and possible interactions of ciprojloxacin and diclofenac in healthy rabbits following intravenous injection. Six male adult chinchilla rabbits were used for the study. In a cross-over design (3 x 2) was used in two phases separated by a wash period (3 weeks), Ciprojloxacin was injected at a dose of30 mg kg-i. They were given intravenously while diclofenac sodium at recommended dose at level of 1 mg kg -i, i.m. to each healthy rabbit. The concentration-time data were analyzed by two-compartmental (after i.v. dose). Plasma concentrations of ciprojloxacin were determined by HPLC. After a washout period, after the drugs were co-administered The kinetic parameters of ciprojloxacin were Significantly changed by administration of diclofenac. Based on these kinetic data, ciprojloxacin is likely to be effective in rabbits even in combination with dicloftnac and suggested for treating infections caused by drugsensitive pathogens in rabbits.

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The purpose ofthis study was to determine the pharmacokinetics and possible interactions of ciprojloxacin and diclofenac in healthy rabbits following intravenous injection. Six male adult chinchilla rabbits were used for the study. In a cross-over design (3 x 2) was used in two phases separated by a wash period (3 weeks), Ciprojloxacin was injected at a dose of30 mg kg-i. They were given intravenously while diclofenac sodium at recommended dose at level of 1 mg kg -i, i.m. to each healthy rabbit. The concentration-time data were analyzed by two-compartmental (after i.v. dose). Plasma concentrations of ciprojloxacin were determined by HPLC. After a washout period, after the drugs were co-administered The kinetic parameters of ciprojloxacin were Significantly changed by administration of diclofenac. Based on these kinetic data, ciprojloxacin is likely to be effective in rabbits even in combination with dicloftnac and suggested for treating infections caused by drugsensitive pathogens in rabbits.

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